gamma-Aminobutyric acid


GABA Molecule : GABA (gamma-aminobutyric acid) helps to modulate the action of dopamine, norepinephrine, and serotonin. Unlike the other neurotransmitters, it occurs almost exclusively in the CNS and is present in a large percentage of neurons of the brain. Several studies have suggested that some individuals with depression have reduced production of GABA, and that it may play a role in the patient's experience of depression and other mental disorders. GABA is considered a primary neurotransmitter because its effects are very specific.

γ-Aminobutyric acid (/ˈɡæmə əˈmiːnoʊbjuːˈtɪrɨk ˈæsɨd/; or GABA /ˈɡæbə/) is the chief inhibitory neurotransmitter in the mammalian central nervous system. It plays the principal role in reducing neuronal excitability throughout the nervous system. In humans, GABA is also directly responsible for the regulation of muscle tone.

Although in chemical terms it is an amino acid, GABA is rarely referred to as such in the scientific or medical communities, because the term "amino acid," used without a qualifier, by convention refers to the alpha amino acids, which GABA is not, nor is it considered to be incorporated into proteins.

In spastic diplegia in humans, GABA absorption becomes impaired by nerves damaged from the condition's upper motor neuron lesion, which leads to hypertonia of the muscles signaled by those nerves that can no longer absorb GABA.


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