Neurotransmitter Reuptake Inhibitor
The SNRIs take advantage of serotonin's positive effects, plus add in
benefits from blocking the reuptake of norepinephrine. These
medications have been available since the early 1990s, and, like the
SSRIs, are generously better tolerated, and safer in overdose than the
tricyclics.

Calculated Glomerular Filtration Rate for Kidney Disease